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Translational Healthcare Scientist

£31,562 - £41,630 / year
Full Time

Job Description

Translational Healthcare Scientist

Great Ormond Street Hospital for Children NHS Foundation Trust (GOSH) is a national centre of excellence in the provision of specialist children's health care, currently delivering the widest range of specialist care of any children's hospital in the UK. It is the only specialist Biomedical Research Centre for paediatrics, the largest centre in the UK for children with heart or brain problems, and the largest centre in Europe for children with cancer. It works in partnership with the UCL Institute of Child Health (ICH), part of University College London, and together they form the largest paediatric research and teaching centre in the UK.

The hospital at Great Ormond Street is the only exclusively specialist children's hospital in the UK. It does not have an Accident and Emergency department and only accepts specialist referrals from other hospitals and community services. The population of children served by the hospital is characterised by those with multiple disabilities and/or health problems and rare and congenital (present at birth) conditions. Many children need the help of different specialist teams. Improvements in health care and diagnosis mean that many children have dramatically improved survival rates and more therapeutic options than was the case 10 years ago. Sadly though, many of the children cared for at GOSH still have life threatening or life-limiting conditions.

The hospital receives over 255,000 patient visits (inpatient admissions or outpatient appointments) a year, and carries our approximately 18,800 operations each year.

The hospital has 383 patient beds, including 44 intensive care beds (21 CICU, 15 PICU and 8 NICU). Many of the children and young people on our wards require high dependency care or are classed as ward intensive care, requiring one-to-one nursing.

Around 4,100 full-time and part-time staff work at the hospital. The ICH has around 600 staff. Many senior staff have roles in both organisations.

The hospital has approximately 50 paediatric specialties, the widest range of any hospital in the UK, which uniquely enables it to diagnose and pioneer treatments for children with highly complex, rare or multiple conditions. It has 19 highly specialised national services.

An exciting opportunity has arisen for a suitably qualified HealthCare Scientist to work within the within the SIHMDS Unit which comes under the umbrella of the Haematology Department. This is a specialist area that provides a wide range of molecular and immunophenotyping services to assist diagnosis in white blood cell, solid tumour, platelet and red blood cell diseases and abnormalities. The post holder will be responsible for the translational development of key highly specialised laboratory tests utilising Next Generation Sequencing (NGS) technology. You will be expected to independently undertake the necessary research and to validate new assays to the required standards to be able to integrate these into routine clinical service provision. In addition the role will require support duties for the laboratory including nucleic acid extraction, PCR, general maintenance and administrative tasks.

Ideally you will have relevant and significant expertise in developing bespoke NGS technology for clinical samples and have a background in molecular procedures using standard technology (e.g. PCR, Sanger sequencing, real time PCR). Practical knowledge and experience with basic Bioinformatics tasks would also be useful in this role.

The successful candidate will have HCPC registration, a BSc in a relevant discipline, experience of developing new assays (preferably using NGS), will have worked in clinical laboratories and have a clear understanding of how to translate research into clinical testing. The successful candidate should have some experience with NGS (specifically with the Illumina MiSeq system), will have some associated bioinformatics skills and have evidence of previous translational work (demonstrated this with scientific publications). Knowledge of Minimal Residual Disease (MRD) testing for childhood Acute Lymphoblastic Leukaemia (ALL) would also be an advantage.

For further information please contact Gary Wright, Lead Healthcare Scientist  ( Phone number removed )  (x5400) or Dr Stuart Adams, Principal Clinical Scientist  ( Phone number removed ) .

Please be advised that:

The closing date given is a guide only. There may be some occasions where we have to close a vacancy once sufficient applications have been received. It is therefore advisable that you submit your application as early as possible to avoid disappointment.

Only those candidates who clearly demonstrate how they meet the person specification criteria for this post will be shortlisted. Please note that where high volumes of applicants have been received, additional criteria may on occasion be used to determine the final shortlist.

Please also note that all recruitment is currently subject to restrictions on the allocation of Certificates of Sponsorship.

We are an accredited Living Wage Employer.

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

Tier 2 Certificate of Sponsorship (formerly a Work Permit)

Applications from job seekers who require Tier 2 sponsorship to work in the UK are welcome and will be considered alongside all other applications. However, non-EEA candidates may not be appointed to a post if a suitably qualified, experienced and skilled EU/EEA candidate is available to take up the post as the employing body is unlikely, in these circumstances, to satisfy the Resident Labour Market Test. The UK Visas and Immigration department requires employers to complete this test to show that no suitably qualified EEA or EU worker can fill the post. For further information please visit the UK Visas and Immigration website.

UK Registration

Applicants must have current UK professional registration. For further information please see applying from overseas.

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